SCIENTIFIC PROGRAM

Thursday, June 13, 2024

8:00 - 8:30 AM    Welcome Coffee

8:30 AM - 8:40 AM    Introduction on behalf of the scientific committee by Alexandre Mebazaa (Paris, FRA)

10:50 AM - 12:00 PM

Session 2: Cardiogenic Shock: Inflammation: a driver of outcome

Moderated by Janine Pöss (Leipzig, GER) & Jason Katz (New York, USA)

Speakers (10 minutes each)

• Inflammation markers and Cardiogenic Shock phenotypes: Sabri Soussi (Toronto, CAN)

• Genotyping: Alastair Proudfoot (London, GBR)

• Phase 2 cardiac surgery trial design: Peter Pickkers (Nijmegen, NED)

• New biomarkers (IL6 and DPP3): Florian Wenzl (Zürich, SUI)

• DPP3 and vascular effect: Adrien Picod (Paris, FRA)

• DOBERMANN trial: Helle Søholm (Copenhagen, DEN)

Panel discussion

Moderated by Janine Pöss (Leipzig, GER) & Jason Katz (New York, USA)

Sabri Soussi (Toronto, CAN), Alastair Proudfoot (London, GBR), Peter Pickkers (Nijmegen, NED), Florian Wenzl (Zürich, SUI), Adrien Picod (Paris, FRA), Helle Søholm (Copenhagen, DEN) & Antoine Herpain (Brussels, BEL)

Paper: Helle Søholm (Copenhagen, DEN) & Florian Wenzl (Zürich, SUI)

12:00 - 1:00 PM Lunch Break

1:00 PM - 3:20 PM

Session 3: Improve Cardiogenic Shock trial design to prevent neutral trial

Moderated by Alain Combes (Paris, FRA) and Susanna Price (London, GBR)

Speakers (10 minutes each)

• We need positive trials: Rhonda Monroe (Charlotte, USA)

• Randomization by patient is not appropriate: Alexandre Mebazaa (Paris, FRA)

• Is clustering by center the answer?: Brian Cuthbertson (Toronto, CAN)

• Control arm should remain "control": Rebecca Mathew (Ottawa, CAN)

• From patient selection to choice of endpoints and to length of follow-up: Mahir Karakas (Hamburg, GER)

• Post-device period is very important: Roberta Bogaev Chapman (Abiomed, USA)

• SOC in a device trial: a challenge: Navin Kapur (Boston, USA)

• Should we include cardiac arrest?: Uwe Zeymer (Ludwigshafen, GER)

• Registry-based randomised trials: David Morrow (Boston, USA)

• eCPR: Roberto Lorusso (Maastricht, NED)

• Win Ratio in critical care: are we ready?: Harriette Van Spall (Hamilton, CAN)

• Industry perspective: Nitin Salunke (Supira Medical, USA)

Panel discussion

Moderated by William O'Neill (Detroit, USA) and Susanna Price (London, GBR)

Rhonda Monroe (Charlotte, USA), Alexandre Mebazaa (Paris, FRA), Brian Cuthbertson (Toronto, CAN), Mahir Karakas (Hamburg, GER), Rebecca Mathew (Ottawa, CAN), Roberta Bogaev Chapman (Abiomed, USA), Navin Kapur (Boston, USA), Uwe Zeymer (Ludwigshafen, GER), David Morrow (Boston, USA), Roberto Lorusso (Maastricht, NED), Harriette Van Spall (Hamilton, CAN), Nitin Salunke (Supira Medical, USA), Chang Fu Wu (FDA,USA), Bram Zuckerman (FDA, USA) & Antoine Herpain (Brussels, BEL)

Paper: Antoine Kimmoun (Nancy, FRA)

3:20 - 3:40 PM Coffee Break

3:40 PM - 4:50 PM

Session 4: Ongoing studies

Moderated by Alessandro Sionis (Barcelona, ESP)

Discussants (5 minutes each)

• DOREMI2: Rebecca Mathew (Ottawa, CAN)

• RECOVER IV: William O'Neill (Detroit, USA)

• Unload VA-ECMO + Impella: Dirk Westermann (Freiburg, GER)

• Altshock-2: Alice Sacco (Milan, ITA)

• ANCHOR: Alain Combes (Paris, FRA)

• LevoHeartShock: Bruno Levy (Nancy, FRA)

• CERAMICS: Mir Babar Basir (Detroit, USA)

• PACCS: Manreet Kanwar (Pittsburgh, USA)

• IV-cangrelor STEMI shock: Sarah Gorgis (Cleveland, USA)

• Continuous Cerebral Autoregulation Monitoring in ECMO Patients - a pilot study: Lucy Zhang (Falls Church, USA)

• Pharmacologic Optimization of Mechanical Support in Cardiogenic Shock – A New Paradigm: Balimkiz Senman (Durham, USA)

• Pilot Trials of Long-Term Subcutaneous EEG for Brain Monitoring in Cardiac Critical Illness: Laith Altaweel (Falls Church, USA)

Panel discussion

Moderated by Alessandro Sionis (Barcelona, ESP)

Rebecca Mathew (Ottawa, CAN), William O'Neill (Detroit, USA), Dirk Westermann (Freiburg, GER), Alice Sacco (Milan, ITA), Alain Combes (Paris, FRA), Bruno Levy (Nancy, FRA), Mir Babar Basir (Detroit, USA), Manreet Kanwar (Pittsburgh, USA), Sarah Gorgis (Cleveland, USA), Lucy Zhang (Falls Church, USA), Balimkiz Senman (Durham, USA) & Laith Altaweel (Falls Church, USA)

Paper: Mireia Padilla Lopez (Barcelona, ESP) & Francesca Manicone (Brussels, BEL)

4:50 - 5:00 PM Coffee Break

5:00 PM - 6:45 PM

Session 5: Positive trials in critical care: the key role of regulators

Moderated by Mona Fiuzat (Arlington, USA), Alexandre Mebazaa (Paris, FRA) and Rhonda Monroe (Charlotte, USA)

Discussants (5 minutes each)

• Patient's Perspective: Rhonda Monroe (Charlotte, USA)

• Investigator Perspective: EU: Thomas Lüscher (Zurich, SUI)

• Investigator Perspective: US: Mitchell Krucoff (Durham, USA)

• Investigator Perspective: Japan: Naoki Sato (Tokyo, JPN)

• Scientific Press perspective: Stuart Spencer (The Lancet, USA)

• Industry Perspective: Chuck Simonton (Abiomed, USA), Karine Bourgeois (4TEEN4, GER), Liesbeth Hof (AM-Pharma, NED)

• Clinician’s Perspective: Ileana Piña (Cleveland, USA)

• Regulators' Perspective: FDA: Kathleen Grunder (FDA, USA) & Jordan Pomeroy (FDA, USA)

• Regulators' Perspective: EMA: Maciej Kostrubiec (EMA, POL)

• NIH Perspective: George Sopko (NHLBI, USA)

Panel discussion

Moderated by Mona Fiuzat (Arlington, USA), Alexandre Mebazaa (Paris, FRA) and Rhonda Monroe (Charlotte, USA)

David Baran (Fort Lauderdale, USA), Rhonda Monroe (Charlotte, USA), Thomas Lüscher (Zurich, SUI), Mitchell Krucoff (Durham, USA), Naoki Sato (Tokyo, JPN), Stuart Spencer (The Lancet, USA), Chuck Simonton (Abiomed, USA), Karine Bourgeois (4TEEN4, GER), Liesbeth Hof (AM-Pharma, NED), Ileana Piña (Cleveland, USA), Kathleen Grunder (FDA, USA), Jordan Pomeroy (FDA, USA), Maciej Kostrubiec (EMA, POL), George Sopko (NHLBI, USA), Mauro Moscucci (FDA, USA) & David Baran (Fort Lauderdale, USA)

6:45 PM - 7:00 PM

Take home messages: Susanna Price (London, UK) and Alexandre Mebazaa (Paris, FRA)

7:00 PM Adjourn & Dinner

Friday, June 14, 2024

8:00 - 8:30 AM Welcome Coffee

8:30 AM - 8:40 AM

Introduction on behalf of the scientific committee by Alexandre Mebazaa (Paris, FRA)

8:40 AM - 11:00 AM

Session 6: Acute Heart Failure: What trials are still needed?

Moderated by Ileana Piña (Cleveland, USA) and Sumeet Mitter (Falls Church, USA)

Speakers (10 minutes each)

• Primary objectives in implementation RCTs: Harriette Van Spall (Hamilton, CAN)

• STRONG-HF: Gad Cotter (Momentum Research, USA)

• What trials I need for my daily practice? Christopher O’Connor (Falls Church, USA)

• Combining effective oral therapies Alexandre Mebazaa (Paris, FRA)

• How to assess combining GDMT and devices? Biykem Bozkurt (Houston, USA)

• Concepts for ADHF Therapeutic Development Mona Fiuzat (Arlington, USA)

• Role of nurses and APPs in implementing therapies: Carolyn Rosner (Falls Church, USA)

• Worsening Heart Failure: how to improve implementation of heart therapies?: Marat Fudim (Durham, USA)

Discussants (5 minutes each)

• Industry perspective: Hela Ben Hamouda (Medtronic International, SUI) & Juuso Blomster (CardioSignal, FIN)

• Patient's perspective: Rhonda Monroe (Charlotte, USA)

Panel discussion

Moderated by Ileana Piña (Cleveland, USA) and Christopher O’Connor (Falls Church, USA)

Harriette Van Spall (Hamilton, CAN), Gad Cotter (Momentum Research, USA), Christopher O’Connor (Falls Church, USA), Alexandre Mebazaa (Paris, FRA), Biykem Bozkurt (Houston, USA), Mona Fiuzat (Arlington, USA), Carolyn Rosner (Falls Church, USA), Marat Fudim (Durham, USA), Hela Ben Hamouda (Medtronic International, SUI), Juuso Blomster (CardioSignal, FIN), Rhonda Monroe (Charlotte, USA), Andrew Farb (FDA, USA) & Maciej Kostrubiec (EMA, POL)

Paper: Mattia Arrigo (Zurich, SUI)

11:00 - 11:30 AM   Coffee Break

11:00 AM - 1:00 PM

Session 7: Management of massive bleeding

Moderated by Sean Collins (Nashville, USA) and Wesley Self (Nashville, USA)

Speakers (10 minutes each)

• Current global recommendations: Natalie Kreitzer (Cincinatti, USA)

• Clinical considerations in hemorrhagic shock in the acute setting: Amelia Maiga (Nashville, USA)

• Investigator’s perspective: Ashkan Shoamanesh (Hamilton, CAN)

• How to generate evidence to manage surgical hemorrhagic shock: Jennifer Gurney (Houston, USA)

Discussants (5 minutes each)

• Industry perspective: Anna Sundgren (AstraZeneca, USA)

• NIH perspective: George Sopko (NHLBI, USA)

Panel discussion

Moderated by Sean Collins (Nashville, USA) and Wesley Self (Nashville, USA)

Natalie Kreitzer (Cincinatti, USA), Amelia Maiga (Nashville, USA), Ashkan Shoamanesh (Hamilton, CAN), Jennifer Gurney (Houston, USA), Anna Sundgren (AstraZeneca, USA), George Sopko (NHLBI, USA), Tek Lamichhane (FDA, USA) & George Gibeily (FDA, USA)

Paper: Anaïs Caillard (Paris, FRA)

1:00 - 2:00 PM Lunch Break

2:00 - 4:30 PM

Session 8: Improving outcomes in the critically ill patients: AI and physicians working hand-in-hand

Moderated by Stephen Browning (FDA, USA) and Etienne Gayat (Paris, FRA)

Keynote lecture (20 minutes)

• AI-based algorithms used in critical care: Romain Pirracchio (San Francisco, USA)

Speakers (10 minutes each)

• AI in ICU: run or hug?: Etienne Gayat (Paris, FRA)

• How can AI help research in my company?: Anna Sundgren (AstraZeneca, USA)

• DEBATE - Impact of AI on scholarly publishing: Emma Grainger (The Lancet, GBR) & Romain Pirracchio (JAMA, USA)

Discussants (5 minutes each)

• Regulatory Perspectives on Artificial Intelligence & Machine Learning: Stephen Browning (FDA, USA)

• How AI start-ups are improving critical care outcomes: Anis Ghorbel (Precisia Care, SUI)

Panel discussion

Moderated by Stephen Browning (FDA, USA) and Etienne Gayat (Paris, FRA)

Romain Pirracchio (JAMA/San Francisco, USA), Anna Sundgren (AstraZeneca, USA), Emma Grainger (The Lancet, GBR), Stephen Browning (FDA, USA), Etienne Gayat (Paris, FRA) & Anis Ghorbel (Precisia Care, SUI)

Paper: Yevgeniy Brailovsky (Philadelphia, USA)

4:30 - 5:00 PM Coffee Break

5:00 - 7:00 PM

Session 9: ARDS 2024 guidelines shape trial design

Moderated by Emma Grainger (The Lancet, GBR) & Christina Barkauskas (Durham, USA)

Speakers (10 minutes each)

• New global definition of ARDS: Michael Matthay (San Francisco, USA)

• Impact of the global definition on future trial design: Sarina Sahetya (San Francisco, USA)

• What are the priorities for future clinical trialists: Maurizio Cecconi (Milan, ITA)

• Ongoing large trials with ECMO: Alain Combes (Paris, FRA)

• Lung Division’s support of ARDS, Pneumonia & Sepsis research: Guofei Zhou (NIH, USA)

• C5A: a promising target in ARDS: Martin Witzenrath (Berlin, GER)

• I-SPY ARDS platform trial design: Derek Russell (Birmingham, USA)

Discussants (5 minutes each)

• Patient perspective: Eileen Rubin (Chicago, USA)

• Industry perspective: Hollmann Aya (Getinge, GER), Axel Vater (Aptarion Biotech, GER) & Negin Hajizadeh (Bayer, USA)

  Panel discussion

  Moderated by Emma Grainger (The Lancet, GBR) & Christina Barkauskas (Durham, USA)

  Michael Matthay (San Francisco, USA), Sarina Sahetya (San Francisco, USA), Alain Combes (Paris, FRA), Guofei Zhou (NIH, USA), Martin Witzenrath (Berlin, GER), Derek Russell (Birmingham, USA), Eileen Rubin (Chicago, USA), Hollmann Aya (Getinge, GER), Axel Vater (Aptarion Biotech, GER) & Negin Hajizadeh (Bayer, USA)

  Paper: Sarina Sahetya (Baltimore, USA)

7:00 PM Adjourn

7:00 PM Cocktail & Dinner in the Embassy of France, Washington D.C.

Saturday, June 15, 2024

8:00 - 8:30 AM Welcome Coffee

8:30 - 8:35 AM Welcome introduction by Alexandre Mebazaa (Paris, FRA)

8:35 AM - 10:40 AM

Session 10: Sepsis I: Endotype-guided therapy

Moderated by Michelle Chew (Malmö, SWE) & Alexandre Mebazaa (Paris, FRA)

Speaker (10 minutes each)

• Is biomarker-guided therapy ready for prime-time?: Bruno François (Limoges, FRA)

• Are other biomarkers of Sepsis ready for prime-time?: Andre Kalil (Omaha, USA)

• BOOST: Pierre-François Laterre (Brussels, BEL)

• Septic shock i-Micro: Matthieu Legrand (San Francisco, USA)

• Digital biomarkers for Sepsis trials: Nathan Shapiro (New Haven, USA)

Discussants (5 minutes each)

• Industry Perspective: Martina Kalle-Brune (Adrenomed, GER), Margarita Salcedo (Inotrem, FRA), Carlos López-Espina (Prenosis, USA) & Thomas Reimer (Bayer, GER), John Kellum (Spectral, USA)

Panel discussion

Moderated by Michelle Chew (Malmö, SWE) & Alexandre Mebazaa (Paris, FRA)

Bruno François (Limoges, FRA), Pierre-François Laterre (Brussels, BEL), Andre Kalil (Omaha, USA), Matthieu Legrand (San Francisco, USA), Nathan Shapiro (New Haven, USA), Martina Kalle-Brune (Adrenomed, GER), Margarita Salcedo (Inotrem, FRA), Carlos López-Espina (Prenosis, USA) & Thomas Reimer (Bayer, GER), Jackie Duda (Frederick, USA), John Kellum (Spectral, USA) & Debra Foster (Spectral Medical, CAN)

Paper: Adrien Picod (Paris, FRA)

10:40 AM - 11:00 AM Coffee Break

11:00 AM - 1:00 PM

Session 11: Sepsis II: Trialists and regulators: can we agree on an endpoint?

Moderated by Nathan Nielsen (Albuquerque, USA) & Diana Stanley (The Lancet, USA)

Speakers (10 minutes each)

• Mortality is dead: Ashish Khanna (Winston-Salem, USA)

• Change in sofa score: Pierre-François Laterre (Brussels, BEL)

• Improvement in organ perfusion: François Dépret (Paris, FRA)

• Organ dysfunction: Margarita Salcedo (Inotrem, FRA)

• Lessons from 2024 European guidelines: Michelle Chew (Malmö, SWE)

Discussants (5 minutes each)

• Patient's Perspective: Jackie Duda (Frederick, USA)

• Regulator's Perspective: Maciej Kostrubiec (EMA, POL)

• Industry Perspective: Melanie Wosnitza (Bayer, GER)

Panel discussion

Moderated by Nathan Nielsen (Albuquerque, USA) & Diana Stanley (The Lancet, USA)

Ashish Khanna (Winston-Salem, USA), Pierre-François Laterre (Brussels, BEL), François Dépret (Paris, FRA), Margarita Salcedo (Inotrem, FRA), Michelle Chew (Malmö, SWE), Eileen Rubin (Chicago, USA), Maciej Kostrubiec (EMA, POL) & Melanie Wosnitza (Bayer, GER)

1:00 PM Adjourn & Lunch

For past editions’ scientific programs, click on the links below: